You open an application, but instead of opening it gives you a notification https://askubuntu.com/questions/1286206/how-to-skip-the-is-ready-notification-and-directly-open-apps-in-ubuntu-20-04
You can maximize but you cannot minimize on click to taskbar https://askubuntu.com/questions/960074/how-do-i-enable-minimize-on-click-on-ubuntu-dock-in-17-10-and-later
Multi monitor problem - You cannot show panel on the second screen https://askubuntu.com/questions/1030460/top-bar-for-all-monitors-ubuntu-with-gnome-shell/1030468#1030468
You cannot drag & drop something to an application on the taskbar https://www.reddit.com/r/gnome/comments/1pmibeu/how_to_do_dragdrop_fromto_an_app_on/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button
GNOME Nautilus File Manager misses many features such as being able to use predefined icons for folders.
Nautilus is not being able to show recent folders https://askubuntu.com/questions/963045/how-can-i-display-recent-folders-in-the-sidebar-of-save-as-dialogue
GNOME Nautilus doesn't show correctly if usb file transformation is finished or not https://askubuntu.com/questions/558196/usb-write-delay-between-when-ubuntu-says-its-done-and-it-actually-being-done
Nautilus cannot even support type-ahead search
https://askubuntu.com/questions/1004227/how-can-i-make-selecting-files-folders-in-the-file-browser-by-typing-a-name-act or https://gitlab.gnome.org/GNOME/nautilus/-/issues/244
GNOME Software is really buggy. you open, you install but it doesn't show its installed, it doesn't update applications before you restart the user session. https://www.reddit.com/r/gnome/comments/1i4auiq/my_reasons_for_why_gnome_software_is_lacking/
GNOME doesn’t include most of the helpful features, so the only way is amazing GNOME extensions. But guess what, on any GNOME upgrade you will get this extension isn’t compatible error until the developer updates.
Just an example: https://extensions.gnome.org/extension/1544/cast-to-tv/
GNOME works really problematic with wayland, most of the time solution is to go back to X11